Intended use

The Fluorescent Immunoassay TT4 POCT kit test is used to evaluate thyroid function and diagnose thyroid disease.

Summary

Thyroxine (T4) is the main hormone secreted by the thyroid gland. It is released into the blood circulation in a free form, and most (more than 99%) are bound to proteins in the plasma, called the bound state. There is also a very small amount of T4 Not bound to proteins in plasma, known as free state. Although conjugated thyroid hormones account for the vast majority in the blood, it is still free thyroid hormones that really play a physiological role. Its main functions are to maintain growth and development, promote metabolism, produce nervous system and cardiovascular effects, affect the growth of long bones and the development of the brain. Total thyroxine (TT4) refers to the sum of free and bound thyroxine in serum, and the detection of TT4 is clinically used as an auxiliary diagnosis of thyroid dysfunction.

Elevated TT4 is seen in:
①hyperthyroidism (including primary, secondary hyperthyroidism, autonomic nodules, T4 hyperthyroidism), thyroid synthesis and secretion of TT4 increase;
②neonatal transient hyperthyroidism;
③subacute hyperthyroidism Thyroiditis and painless thyroiditis (such as chronic lymphocytic thyroiditis);
④ taking a large amount of thyroxine and animal thyroid;
⑤oral contraceptives, estrogen, hepatitis, hereditary TBG increase, drug abuse, etc. can all increase TT4;
⑥TSH inappropriate secretion syndrome increased.

Reduced TT4 is seen in:
①When thyroid function is reduced, TT4 is reduced;
②Thyroid deficiency, or congenital dysplasia, blood TT4 deficiency after total thyroidectomy;
③ Various non-thyroid diseases, such as various liver diseases, liver cirrhosis, hepatic coma, Kidney disease, renal failure, myocardial infarction, severe respiratory and digestive diseases, infectious diseases, trauma, burns, hunger, protein malnutrition, diabetes, etc., can all lead to low T3 syndrome, and TT4 is also reduced in severe cases. A significant decrease in TT4 indicates a poor prognosis in critical condition. After remission,TT4 returned to normal.

This Fluorescent Immunoassay TT4 POCT kit is reliable for the diagnosis of hyperthyroidism, primary and secondary, and TT4 inhibition of treatment. The current clinical methods for detecting TT4 include chemiluminescence, immunochromatography, etc.

PRODUCT PARAMETER

TEST PARAMETER
Method	Microfluidic Fluorescent Immunoassay	Test	LYOFIA® TT4
Format	Cassette	Reaction Time	10min
Linearity	8～240ng/mL	Reference Interval	45～109ng/mL
Sample	WB / S / P	Certificate	CE / NMPA

ORDERING
Cat. No.	LMTHT425	Applicable analyzer	LYOFIA-I, LYOFIA 8,	Kit Size	25T
Cat. No.	LATHT425	Applicable analyzer	LYOFIA 100 (Full-Automatic)	Kit Size	25T