PRODUCT INTRODUCTION
Intended use
This Total Vitamin D FIA Test is based on the fluorescence immunoassay method for the quantitative detection of Vitamin D in multiple human samples by self-developed LYOFIA® system, including whole blood, serum and plasma sample.
For in vitro diagnostic use only.
Summary
Vitamin D is a fat-soluble vitamin, which is a cyclopentane polyhydrophenanthrene compound. It is a group of vitamins that are structurally related to sterols and can prevent rickets functionally. The most important ones are vitamins D3 and D2. The former is produced by irradiating 7-dehydrocholesterol under human skin with ultraviolet light. The latter is produced by irradiating ergosterol contained in plants or yeast with ultraviolet light. The main function of vitamin D is to promote the absorption of calcium and phosphorus by the intestinal mucosal cells. The absorption of calcium ions in the intestine requires a calcium-binding protein. 1,25-dihydroxyvitamin D3 can induce the synthesis of this protein, promote Ca2+ absorption, promote the renewal of calcium salts and new bone formation, and also promote phosphorus absorption and renal tubular cells. Reabsorption of calcium and phosphorus can increase blood calcium and blood phosphorus concentrations, which is beneficial to new bone formation and calcification.
Vitamin D mainly comes from ultraviolet rays in the sun and skin synthesis. When there is vitamin D deficiency, you should spend as much time in the sun as possible. In addition, you can also absorb vitamin D through diet in your daily life, such as eating more lean meat, dairy products, fresh fruits and vegetables, and eating more seafood rich in vitamin D, such as deep-sea fish, eggs, liver, etc. .
Why Test Vitamin D ?
Vitamin D measurement is mainly used to determine the level of activated vitamin D in serum and is also an important clinical diagnostic indicator of osteoporosis. The normal value of vitamin D measurement is usually 20-50ng/mL. If the measurement is <20ng/mL, it is a vitamin D deficiency. If it is <10ng/mL, it indicates a severe vitamin D deficiency. At this time, vitamin D should be supplemented to 30ng /mL or more.
A blood test for vitamin D can determine whether osteoporosis has occurred. Pathological elevations of vitamin D in the blood can be seen in tuberculosis, lymphoma, hypercalcemia, and kidney stones, and serum vitamin D levels in children are higher than in adults. If children are deficient in vitamin D, they may develop vitamin D deficiency rickets, which manifests as irritability, excessive sweating, bone deformities, and muscle laxity. If adults are deficient in vitamin D, it can mainly manifest as osteoporosis, muscle weakness, easy falls and fractures, etc. In severe cases, it can lead to osteomalacia.
Benefit
· Accurate
1Total Vitamin D FIA test, 3 results: Total Vitamin D, D2, D3.
The CV. of Repeatability and within-laboratory imprecision is no more than 10%,the CV. of inter-lot imprecision is no more than 15%.
· Fast
The Total Vitamin D FIA TEST detects the levels of Vitamin D in blood samples within just 10 minutes.
· Easy to use
Without the use of cumbersome laboratory equipment, but just requiring minimally trained laboratory personnel.
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