Structure, synthesis and secretion of BNP

Like ANP, BNP has a ring structure composed of 17 amino acids through a pair of disulfide bonds, which is necessary for receptor binding, and the disulfide bonds are very important for the biological activity of BNP. BNP is species-specific. Rat BNP consists of 45 amino acids, while pig, dog and human BNP consists of 32 amino acids. The human BNP gene fragment is located at the distal end of the short arm of chromosome 1, and its upstream ANP fragment Connected, its reverse transcription deoxyribonucleic acid (cDNA) consists of 1900 nucleotides, and the BNP messenger ribonucleic acid (mRNA) consists of 900-1000 nucleotides, which can be expressed as a BNP precursor, and the N-terminal is removed. The signal peptide becomes a BNP precursor (proBNP) containing 108 amino acids, but is not stored in the secretory granules, mainly secreted from the ventricle, and decomposed into biologically active BNP (containing 32 amino acids) during its secretion or after entering the blood. C-terminal fragment) and N-terminal fragment. Left ventricular extension and wall tension basally regulate BNP release.