PRODUCT INTRODUCTION
Soluble growth stimulation gene-2 (sST2), as a new biomarker that can simultaneously reflect inflammation, fibrosis and myocardial tension, can be used for risk stratification,Prognosis assessment and individualized treatment.
The Fluorescence immunoassay sST2 POCT Kit test is suitable for quantitative detection in vitro.
Summary
sST2 is a member of the interleukin-1 receptor family, also known as interleukin-1 receptor-like 1 (IL1RL-1). Transmembrane or cellular form of ST2 (ST2L) and soluble or circulating form of ST2 (sST2). ST2 is the receptor for interleukin-33 (IL-33); IL-33 is an IL-1-like cytokine secreted by living cells in response to cellular injury. Experimental models have demonstrated that the combination of IL-33 and ST2L has a protective effect on the heart, reducing myocardial fibrosis, cardiomyocyte hypertrophy and apoptosis.
sST2 is a novel biomarker that can simultaneously reflect inflammation, fibrosis and myocardial stretch. Compared with other biomarkers, sST2 has lower biological variability, and can better perform risk stratification, prognosis assessment and guide individualized treatment in patients with acute and chronic heart failure. The performance of this fluorescent immunoassay sST2 POCT kit has been verified, and it can be combined with NT-proBNP to improve the diagnostic value of heart failure.Although sST2 is not affected by age, body mass index (BMI), atrial fibrillation, and neprilysin inhibitors, unlike BNP and NT-proBNP, it can be affected by asthma, pulmonary fibrosis, rheumatoid arthritis, and collagen vascular disease. , sepsis, trauma, malignant tumors and other diseases where the TH2 immune response is dominant, it is abnormally elevated, so it should be noted whether it is combined with the above-mentioned diseases in its clinical application.
FAQ
Q:What are the sample types?
A: Whole blood, serum and plasma are applicable.
Q: How about detection time
A: About 10mins.
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