POCT For Heparin Anticoagulation Monitoring

Heparin monitoring is quite frequent in hospitalized patients, especially in supervised patients, and long wait times hinder rapid diagnosis of coagulation disorders and rapid and effective anticoagulation. Although the application of POCT for domestic heparin monitoring is relatively mature, it is actually limited to ACT measurement. ACT is not the only choice. POCT for APTT detection provides this possibility. Heparin anticoagulation monitoring is interfered by many factors, such as heparin overdose, protamine, acquired factor deficiency, DIC, and primary fibrinolysis. For a wide range of reasons, such as individual, instrument or reagent differences, it is difficult to establish a relationship between anticoagulation effect and how much prolonged agglutination is. Through the investigation, it was found that the correlation of APTT between POCT and automated instruments was not ideal, and the consistency of APTT was far less than that of PT. Because it is not calibrated and calculated like INR, the seconds of APTT are basically incomparable, POCT is slightly higher than the result of automatic coagulation instrument, and the measurement range is wide, which is inconvenient to compare in the high value range. Because the APTT test itself is very sensitive to reagents, the results of the automated coagulation instrument combined with different APTT reagents to determine the same plasma are inconsistent, and the difference between patients treated with heparin is as high as 200%. POCT technology has different methodological characteristics from automated coagulation instruments. Even if the detection of quality control specimens has a certain correlation, the differences are difficult to ignore.