Formation of NT-proBNP:
Clinical significance of NT-proBNP in heart failure：
1. Diagnosis and exclusion of acute heart failure
2. Diagnosis and treatment of chronic heart failure
NT-proBNP improves the accuracy of clinical diagnosis:
2008 ESC Heart Failure Guidelines:
BNP/NT-proBNP is the best biomarker for diagnosis and exclusion of HF.
The clinical application value in the diagnosis and exclusion of heart failure is equivalent to that of ultrasound, but it’s simpler and faster, and is suitable for emergency use.
International experts consensus defines the diagnostic criteria for chronic heart failure as below:
| <400pg/mL | Basically exclusion of HF |
| 400~2000pg/mL | Possibly has HF |
| >2000pg/mL | Basically determined to be heart failure |
Recommended Heart Failure Markers--NT-proBNP:
Serum markers detection is one of the important means for the early diagnosis and prognosis of heart failure in clinical practice. Among them, natriuretic peptides (a neuroendocrine system activation marker), including brain natriuretic peptide (BNP) and amino-terminal brain natriuretic peptide (NT-proBNP) as preferred serum markers for heart failure and recommended by famous Heart Failure Guidelines (ECS/ACC/AHA/HFSA/CSC). #Cardiac Marker POCT #B-type Natriuretic Protein (BNP) Kit #N-terminal proBNP (NT-proBNP) test kit #NT-proBNP test kit
The difference between the biological properties of NT-proBNP and BNP:
